Chromosome analysis of nine osteosarcomas

摘要: Although recurrent chromosome abnormalities have been identified in several histologic subtypes of sarcomas, no consistent rearrangement has yet found osteosarcomas. Cytogenetic analyses nine cases osteosarcoma are reported, including seven newly diagnosed tumors and two tumors. There were high-grade osteosarcomas, one periosteal osteosarcoma, well-differentiated sarcoma. All studied short-term primary culture. Modal number ranged from near diploid to triploid. Seven had complex karyotypes with multiple structural abnormalities; only normal karyotypes. The retinoblastoma gene on 13 the TP53 17 involved osteosarcoma. Five loss a whole copy 13, three these also 17. However, losses observed setting numerous other loses. Numerous observed, many involving additions unidentified material, unbalanced translocations, or deletions. Structural similar breakpoints 6q, 8q, 9q, 14p seen each. When this series added 18 published cases, pericentromeric regions chromosomes 1, 3, 14, segments 6q 15-21, 8q24, 9q34, 12p 17p 19q be five more rearrangements. Molecular may yield genes important pathogenesis Genes Chrom Cancer 9:88-92 (1994).© 1994 Wiley-Liss, Inc.