The TrK Receptor Family
作者： Hubert Hondermarck , Yohann Demont , Ralph A. Bradshaw
DOI: 10.1007/978-3-319-11888-8_17
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摘要: The Trk family is composed of three principal members (A, B and C), also termed neurotrophin tyrosine kinase receptors (NTRK1, NTRK2, NTRK3), with several additional splice variants, which in humans are located on different chromosomes (1, 9, 15). proteins for the growth factors (NGF, BDNF, NT-3, NT4/5); they bind respond more weakly to proforms these neurotrophins. Both neurotrophins pro-neurotrophins utilize other (p75NTR, sortilin) that can interact Trks affect their activity. predominantly expressed nervous tissues, where essential growth, development, maintenance select types both peripheral central neurons involved neurodegenerative diseases. found some nonneuronal tissues a wide variety tumors, play an active role tumor progression metastasis. activated primarily signal through Shc, FRS2, PLCγ, turn activate PI3K, Erks, hydrolysis inositol phospholipids, among events, leading modulation gene transcription.
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