Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma.
作者： Spela Kos , Alessandra Lopes , Veronique Preat , Maja Cemazar , Ursa Lampreht Tratar
DOI: 10.1371/JOURNAL.PONE.0217762
关键词:
摘要: We aimed to explore whether the combination of intradermal DNA vaccination, boost immune response against melanoma antigens, and checkpoint blockade, alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 tumor model. Compared single treatments, vaccination (ovalbumin or gp100 plasmid adjuvanted with IL12 plasmid) CTLA-4/PD-1 blockade resulted significant delay growth prolonged survival treated mice. Strong activation induced by combined treatment antigen-specific response, elevated production IgG antibodies increased intratumoral CD8+ infiltration. These results indicate potential application specifically, enhance efficacy vaccines overcome resistance inhibitors certain cancer types.
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