Increased adherence of CD2 peripheral blood lymphocytes to cytomegalovirus-infected fibroblasts is blocked by anti-LFA-3 antibody.

摘要: In the accompanying manuscript (p. 405) we describe up-regulation of adhesion molecules LFA-3 and ICAM-1 on surface cytomegalovirus (CMV)-infected fibroblasts from days 1 to 5 post-infection. Peak expression was seen day 2, when twice, three times, level uninfected fibroblasts. The present study demonstrates a parallel increase in peripheral blood leucocytes CMV-infected fibroblasts, which significantly greater than 2 4 This effect 24 hr leucocyte-fibroblast co-culture. increased binding infected accounted for by CD2+ subset lymphocytes. All subpopulations lymphocytes, namely CD3+, CD4+, CD8+ cells, demonstrated suggesting that CD2-LFA-3 interaction an important component binding. proposal supported fact pretreatment with monoclonal antibodies specific LFA-3, blocked Supernatants or co-cultures could transfer leucocyte CMV might accentuate inflammatory responses. As lymphocytes can be activated CD2 pathway, also provoke nonspecific responses as well possibly contribute tissue damage.