Macrophages: Microbial Recognition and Response

摘要: Macrophages are derived from circulating monocytes and found in all tissues throughout the body, especially lung, spleen, liver, bone marrow. The macrophage scavenger receptors were discovered by Brown Goldstein functionally described for their ability to bind modified low-density lipoproteins (LDLs), such as acetylated LDL (AcLDL) oxidized (OxLDL), but not native molecules. This chapter focuses on macrophages. Macrophage receptor with a collagenous structure (MARCO) is constitutively expressed subpopulations of macrophages, particular, those spleen marginal zone, medullary lymph nodes, resident peritoneal C-type lectin recognize carbohydrates cell surfaces, proteins, pathogens. have numerous that involved phagocytosis/endocytosis, play role sensing microbial products inducing signal transduction. surfactant proteins altering function by, example, upregulating expression mannose SR-A, thereby improving pathogen phagocytosis. most important opsonins complement immunoglobulins, immunoglobulin G (IgG). Many cytokine interact cytoplasmic kinases Janus kinase (JAK) family, which initiate response through transducer activator transcription (STAT) produce wide range cytokines, include interleukin molecules (IL), tumor necrosis factors (TNF), chemokines (CC CXC). Receptor ligation mediates many processes including phagocytosis, production cytokines chemokines, ultimately activation humoral immune invading