Metaxins 1 and 2, two proteins of the mitochondrial protein sorting and assembly machinery, are essential for Bak activation during TNF alpha triggered apoptosis.
作者： Pierre-François Cartron , Elise Petit , Grégory Bellot , Lisa Oliver , François M. Vallette
DOI: 10.1016/J.CELLSIG.2014.04.021
关键词:
摘要: The proteins Bax and Bak are central in the execution phase of apoptosis; however, little is known about partners involved control this complex process. Here, we show that mitochondrial incorporated into a VDAC2/Mtx1/Mtx2 multi-protein both resting dying cells. VDAC2 porin has previously been described as partner while Mtx1 Mtx2 two sorting assembly machinery (SAM) have implicated TNF-induced apoptosis. We that, after induction apoptosis, switches from its association with to interact Mtx1.
sci-hub.se 参考文章(37)
Diana Stojanovski, Nikolaus Pfanner, Nils Wiedemann, Import of proteins into mitochondria. Methods in Cell Biology. ,vol. 80, pp. 783- 806 ,(2007) , 10.1016/S0091-679X(06)80036-1
Martin Ott, Erik Norberg, Katharina M. Walter, Patrick Schreiner, Christian Kemper, Doron Rapaport, Boris Zhivotovsky, Sten Orrenius, The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release Journal of Biological Chemistry. ,vol. 282, pp. 27633- 27639 ,(2007) , 10.1074/JBC.M703155200
Malena B. Rone, Jun Liu, Josip Blonder, Xiaoying Ye, Timothy D. Veenstra, Jason C. Young, Vassilios Papadopoulos, Targeting and insertion of the cholesterol-binding translocator protein into the outer mitochondrial membrane. Biochemistry. ,vol. 48, pp. 6909- 6920 ,(2009) , 10.1021/BI900854Z
Mats Gullberg, Simon Fredriksson, Michael Taussig, Jonas Jarvius, Sigrun Gustafsdottir, Ulf Landegren, A sense of closeness: protein detection by proximity ligation. Current Opinion in Biotechnology. ,vol. 14, pp. 82- 86 ,(2003) , 10.1016/S0958-1669(02)00011-3
Richard J. Youle, Andreas Strasser, The BCL-2 protein family: opposing activities that mediate cell death Nature Reviews Molecular Cell Biology. ,vol. 9, pp. 47- 59 ,(2008) , 10.1038/NRM2308
Thomas Becker, F.-Nora Vögtle, Diana Stojanovski, Chris Meisinger, Sorting and assembly of mitochondrial outer membrane proteins. Biochimica et Biophysica Acta. ,vol. 1777, pp. 557- 563 ,(2008) , 10.1016/J.BBABIO.2008.03.017
G Bellot, P-F Cartron, E Er, L Oliver, P Juin, L C Armstrong, P Bornstein, K Mihara, S Manon, F M Vallette, TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax Cell Death & Differentiation. ,vol. 14, pp. 785- 794 ,(2007) , 10.1038/SJ.CDD.4402055
Emily H-Y Cheng, Tatiana V Sheiko, Jill K Fisher, William J Craigen, Stanley J Korsmeyer, VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science. ,vol. 301, pp. 513- 517 ,(2003) , 10.1126/SCIENCE.1083995
K Ross, T Rudel, V Kozjak-Pavlovic, TOM-independent complex formation of Bax and Bak in mammalian mitochondria during TNF alpha-induced apoptosis Cell Death & Differentiation. ,vol. 16, pp. 697- 707 ,(2009) , 10.1038/CDD.2008.194
Thibaud T. Renault, Xavier Grandier-Vazeille, Hubert Arokium, Gisèle Velours, Nadine Camougrand, Muriel Priault, Oscar Teijido, Laurent M. Dejean, Stéphen Manon, The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast FEBS Letters. ,vol. 586, pp. 116- 121 ,(2012) , 10.1016/J.FEBSLET.2011.12.003