Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP2C19 genotype

摘要: SummaryBackground Acid inhibitory effects of proton pump inhibitors (PPIs) are influenced by CYP2C19 genotype. In contrast, the potent acid inhibition vonoprazan is not genotype. Aim To compare and esomeprazole in relation to genotype. Methods Twenty-eight healthy Japanese volunteers [7 poor metabolisers (PMs), 11 intermediate (IMs) 10 rapid (RMs)] received four different regimens a randomised crossover manner: (i) 20 mg twice daily (b.d.), (ii) daily, (iii) b.d. (iv) daily. The timing each dosing was 1 h before meal. Twenty-four-hour intragastric pH monitoring performed on day 7 regimen. Results In overall genotype group, ≥4 holding time ratios (pH 4 HTRs) with b.d., were 100%, 95%, 91%, 68% respectively. 5 HTRs 99%, 84% 54% Vonoprazan potently suppressed for 24 h, significantly superior other irrespective equivalent IMs PMs, but RMs. genotype-dependent differences observed or daily. Conclusion Vonoprazan inhibits genotype, more than reached 100%