摘要: Cognitive dysfunction, which occurs in 80% of people with traumatic brain injury (TBI), is associated upregulation phosphodiesterase 4B2 (PDE4B2). In an animal study, researchers examined the potential usefulness PDE4B inhibitor A33 for cognitive manifestations artificially induced TBI. Rats underwent surgery sham or experimental TBI. Experimental but not TBI caused learning and working-memory deficits, were …
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D. J. Titus, N. M. Wilson, J. E. Freund, M. M. Carballosa, K. E. Sikah, C. Furones, W. D. Dietrich, M. E. Gurney, C. M. Atkins, Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor. The Journal of Neuroscience. ,vol. 36, pp. 7095- 7108 ,(2016) , 10.1523/JNEUROSCI.3212-15.2016