Serotonin augments the cationic current Ih in central neurons.

摘要: Abstract Serotinin (5-HT) induced a slow depolarization when superfused onto neurons of the rat brainstem nucleus prepositus hypoglossi (PH) in vitro. The was associated with decrease cell input resistance. In voltage clamp, 5-HT caused an inward current that activated at approximately −50 mV and present only potentials negative to this. With hyperpolarizing voltage-clamp steps, PH exhibited relaxation. properties this conductance were consistent cationic, nonselective current, I h Bath-applied augmented . Extracellular CsCI blocked both produced by 5-HT. addition, forskolin, isobutylmethylxanthine, 8-bromo-CAMP mimicked seen 1 agonist 5-carboxamidotryptamine similar current. We conclude excites augmenting , probably through receptor-mediated stimulation adenylate cyclase. As is found many types neurons, mechanism may be common mode regulating excitability.