Microglia digest Staphylococcus aureus into low molecular weight biologically active compounds

摘要: Excess sleep and fever are central nervous system (CNS) facets of the acute phase response; these responses induced by microbial products, such as muramyl peptides, via their ability to enhance cytokine production. Although peripheral macrophages known digest bacteria, thereby releasing peptides that, in turn, stimulate production, it was unknown whether CNS phagocytes microglia also had this capacity. Primary cultures were allowed phagocytize Staphylococcus aureus radiolabeled with a cell wall-specific marker. Radiolabeled low molecular weight substances released into culture medium partially purified tested for induce excess sleep, fever, These increased non-rapid eye movement electroencephalographic slow-wave activity, brain temperature after intracerebroventricular injection rabbits. They interleukin-1, tumor necrosis factor, interleukin-1 receptor antagonist production human monocytes. Results suggest that perform fundamental macrophage functions further implicate resident immunocompetent cells.