Lipocalin-2 is an inflammatory biomarker associated with metabolic abnormalities in Egyptian obese children
作者： Moushira Zaki , Hala El-Bassyouni , Eman Youness , Nadi Mohamed
关键词:
摘要: Article history: Results: In the present cross -section study serum lipocalin-2, leptin, insulin, HOMA-IR blood pressure, triglycerides and low-density lipoprotein (LDL-c) cholesterol were significantly higher in obese children than non-obese, whereas high-density (HDL-c) was lower. After adjustment of lipocalin-2 levels for BMI, age gender, correlation between with weight, waist circumference, body fat % metabolic variables such as fasting insulin; glucose triglycerides, cholesterol, LDL-C HDL-C remained significant. The stepwise multiple regression analysis showed that independently associated LDL-c, total HOMA-IR. Conclusions: elevated prepubertal adiposity parameters its related complications. findings suggest measurement this biomarker may be useful evaluating syndrome Egyptian children.
sci-hub.st 参考文章(36)
Susan K. Fried, Matthew R. Ricci, Colleen D. Russell, Blandine Laferrère, Regulation of Leptin Production in Humans Journal of Nutrition. ,vol. 130, ,(2000) , 10.1093/JN/130.12.3127S
S M Van Bun, L M Fransen, J G Raymackers, J J Van Beeumen, H A Blockx, A Van de Voorde, L A Meheus, Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. Journal of Immunology. ,vol. 151, pp. 1535- 1547 ,(1993)
Takashi Kadowaki, Toshimasa Yamauchi, Adiponectin and Adiponectin Receptors Endocrine Reviews. ,vol. 26, pp. 439- 451 ,(2005) , 10.1210/ER.2005-0005
Loredana Quadro, William S Blaner, Daniel J Salchow, Silke Vogel, Roseann Piantedosi, Peter Gouras, Sarah Freeman, Maria P Cosma, Vittorio Colantuoni, Max E Gottesman, Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein The EMBO Journal. ,vol. 18, pp. 4633- 4644 ,(1999) , 10.1093/EMBOJ/18.17.4633
Ying Lin, Michael W. Rajala, Joel P. Berger, David E. Moller, Nir Barzilai, Philipp E. Scherer, Hyperglycemia-induced Production of Acute Phase Reactants in Adipose Tissue Journal of Biological Chemistry. ,vol. 276, pp. 42077- 42083 ,(2001) , 10.1074/JBC.M107101200
K. M. Choi, T. N. Kim, H. J. Yoo, K. W. Lee, G. J. Cho, T. G. Hwang, S. H. Baik, D. S. Choi, S. M. Kim, Effect of exercise training on A‐FABP, lipocalin‐2 and RBP4 levels in obese women Clinical Endocrinology. ,vol. 70, pp. 569- 574 ,(2009) , 10.1111/J.1365-2265.2008.03374.X
Pilar Codoñer-Franch, Sandra Tavárez-Alonso, Raquel Simó-Jordá, Paz Laporta-Martín, Arturo Carratalá-Calvo, Eulalia Alonso-Iglesias, Vitamin D Status is Linked to Biomarkers of Oxidative Stress, Inflammation, and Endothelial Activation in Obese Children The Journal of Pediatrics. ,vol. 161, pp. 848- 854 ,(2012) , 10.1016/J.JPEDS.2012.04.046
Theodoros Zografos, Alexander Haliassos, Socrates Korovesis, Eleftherios Giazitzoglou, Eutychios Voridis, Demosthenes Katritsis, Association of neutrophil gelatinase-associated lipocalin with the severity of coronary artery disease. American Journal of Cardiology. ,vol. 104, pp. 917- 920 ,(2009) , 10.1016/J.AMJCARD.2009.05.023
Quansheng Liu, Marit Nilsen-Hamilton, Identification of a new acute phase protein. Journal of Biological Chemistry. ,vol. 270, pp. 22565- 22570 ,(1995) , 10.1074/JBC.270.38.22565
V. Wallenius, E. Elias, G. M. L. Bergstrom, H. Zetterberg, C. J. Behre, The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men. Experimental and Clinical Endocrinology & Diabetes. ,vol. 119, pp. 75- 80 ,(2010) , 10.1055/S-0030-1265212