Evolution of SR protein and hnRNP splicing regulatory factors.

摘要: The splicing of pre-mRNAs is an essential step gene expression in eukaryotes. Introns are removed from split genes through the activities spliceosome, a large ribonuclear machine that conserved throughout eukaryotic lineage. While unicellular eukaryotes characterized by less complex splicing, pre-mRNA multicellular organisms often associated with extensive alternative significantly enriches their proteome. selection splice sites and exons permits to modulate patterns cell type-specific fashion, thus contributing functional diversification. Alternative regulated process mainly influenced regulators, such as SR proteins or hnRNPs. These modular factors have evolved common ancestor duplication events diverse group regulators mediate exon recognition sequence-specific binding pre-mRNAs. Given strong correlations between intron expansion, complexity emergence it argued increased presence hnRNP promoted evolution relaxation sequence requirements junctions.