摘要: Ultraviolet, circular dichroism spectroscopies were used to examine the acid-base equilib-rium of a double-helix synthetic polyadenyl-polyuridyl Poly(A)-Poly(U) acid in neutral and alkaline aqueoussolutions. The deprotonation initially has positive cooperativity which changes for negative at degree α > 1/2. A model is proposed, that explains titration curves complex dependence pKa on pH going from region. based allowance effect immediate environment internal protonation constant ideal polymer.
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