The mechanism of healing of tympanic membrane perforations. A two-dimensional histological study in guinea pigs.

摘要: The healing of small perforations, made in 60 tympanic membranes (30 guinea pigs) with either a thermal myringotome or needle was observed over 10-day period using an operating microscope. Thirty-six these were sectioned parallel the handle malleus, at right angles to it, and closing perforations studied by light microscopy. epidermis closed first, direction surface migration. This process began within 48 hours complete 9 days. A fibrous reaction occurred, starting 3 days, this seen on side perforation adjacent malleus bony annulus. There no response visible middle ear mucosa. conclusion study is that first layer close because its migratory function, closure Healing occurs secondarily, site related vascula...