Clinical Studies of Long-Term Estrogen Therapy in Men with Myocardial Infarction

摘要: Conclusions and summary1. In a clinical trial men with coronary artery disease who had recovered from frank myocardial infarction were randomly treated Lynoral (ethinyl estradiol), Anvene, Premarin, or placebo. The 3 estrogen preparations used in small well-tolerated doses of comparable potency as indicated by mild breast tenderness. 2. No untoward effects the treatment observed up to 60 months continuous treatment. Changes libido rarely noted. 3. Premarin therapy significantly improved survival, particularly first 2 years estradiol) Anvene no effect on survival compared placebo 4. Subclasses patients most likely benefit those relatively poor initial prognosis: under age 55, infarction, complications arteriosclerotic heart present. 5. lowered cholesterol-phos...