On the role of surface composition and curvature on biointerface formation and colloidal stability of nanoparticles in a protein-rich model system.

摘要: Abstract The need for a better understanding of nanoparticle–protein interactions and the mechanisms governing resulting colloidal stability has been emphasised in recent years. In present contribution, short long term silica nanoparticles (SNPs) silica–poly(ethylene glycol) nanohybrids (Sil–PEG) have scrutinised protein model system. Well-defined are rapidly covered by bovine serum albumin (BSA) form small clusters after 20 min while large agglomerates detected 10 h depending on both particle size ratio. Oppositely, Sil–PEG hybrids suppressive adsorption enhanced solution. No critical agglomeration was found either system absence protein, proving that instability SNPs must arise as consequence not to high ionic environment. Analysis angle X-ray scattering (SAXS) structure factor indicates short-range attractive potential between particles silica-BSA system, which is good agreement with bridging mechanism. results presented here point out importance nanoparticle surface properties ability adsorb proteins how induced or depressed may potentially drive stability.