Novel concepts in insulin regulation of hepatic gluconeogenesis
作者： Andreas Barthel , Dieter Schmoll
DOI: 10.1152/AJPENDO.00253.2003
关键词:
摘要: The regulation of hepatic gluconeogenesis is an important process in the adjustment blood glucose level, and pathological changes production liver are a central characteristic type 2 diabetes. pharmacological intervention signaling events that regulate expression key gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) catalytic subunit glucose-6-phosphatase (G-6-Pase) regarded as potential strategy for treatment metabolic aberrations associated with this disease. However, such requires detailed understanding molecular mechanisms involved process. Glucagon glucocorticoids known to increase by inducing PEPCK G-6-Pase. coactivator protein PGC-1 has been identified mediator regulation. In contrast, insulin suppress both G-6-Pase gene activation PI 3-kinase. 3-kinase-independent pathways can also lead inhibition enzymes. This review focuses on nuclear transduce
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