Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese.

摘要: Polymorphisms in the gene for microsomal epoxide hydrolase (mEPHX), an enzyme involved protective mechanism against oxidative stress, have been reported to be associated with individual susceptibility development of chronic obstructive pulmonary disease (COPD). The polymorphisms exons 3 and 4 mEPHX were examined a total 358 Japanese individuals, including 40 patients COPD 71 lung cancer. overall frequencies variant allele codons 113 (exon 3) 139 4) 44% 14%, respectively. Moreover, novel single nucleotide polymorphism (estimated frequency: 0.29) was identified at 20 bp downstream codon strong linkage disequilibrium wild 113. While proportions individuals homozygous 113, assumed having very slow activity, similar among or cancer control population, they significantly higher severe than those mild [P=0.0225, odds ratio 2.9 (95%CI 1.1-7.4); P=0.0350, respectively]. Thus, we found that frequency is Caucasians (P=0.0028), silent exists exon shows variants may advanced rather COPD.