Inactivation of the dorsal raphé nucleus reduces the anxiogenic response of rats running an alley for intravenous cocaine.
作者： Aaron Ettenberg , Oren A. Ofer , Carl L. Mueller , Stephanie Waldroup , Ami Cohen
DOI: 10.1016/J.PBB.2010.11.008
关键词:
摘要: Rats traversing a straight alley once day for delivery of single i.v. injection cocaine develop over trials an ambivalence about entering the goal box. This is characterized by increasing occurrence "retreat behaviors" where animals leave start box and run quickly to box, but then stop at entry point "retreat" back toward unique pattern retreat behavior has been shown reflect form "approach-avoidance conflict" that stems from animals' concurrent positive (cocaine reward) negative (cocaine-induced anxiety) associations with Cocaine blocks reuptake serotonergic (5-HT) transporter serotonin implicated in modulation anxiety. It was therefore interest determine whether inactivation cell bodies residing dorsal raphe nucleus (DRN) projecting brain areas critical anxiety, would alter anxiogenic state exhibited rats running daily injections 1.0mg/kg cocaine. Reversible DRN accomplished intracranial application mixed solution GABA agonists baclofen muscimol. While had no impact on subjects' motivation initiate responding (i.e., latencies were unaffected) it reliably reduced frequency approach-avoidance behaviors (conflict behavior). These data suggest reduces conflict/anxiety otherwise present experienced cocaine-seeking animals.
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