Comparison of requirements and capabilities of major multipurpose software packages.

作者: Robert P. Igo , Audrey H. Schnell

DOI: 10.1007/978-1-61779-555-8_30

关键词:

摘要: The aim of this chapter is to introduce the reader commonly used software packages and illustrate their input requirements, analysis options, strengths, limitations. We focus on that perform more than one function include a program for quality control, linkage, association analyses. Additional inclusion criteria were (1) programs are free academic users (2) currently supported, maintained, developed. Using those criteria, we chose review three programs: Statistical Analysis Genetic Epidemiology (S.A.G.E.), PLINK, Merlin. will describe required format options. not go into detail about every possible in packages, but give an overview requirements capabilities.

参考文章(41)
C. I. Amos, Robust variance-components approach for assessing genetic linkage in pedigrees. American Journal of Human Genetics. ,vol. 54, pp. 535- 543 ,(1994)
Sobel E, Lange K, Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. American Journal of Human Genetics. ,vol. 58, pp. 1323- 1337 ,(1996)
Kenneth Lange, An approximate model of polygenic inheritance. Genetics. ,vol. 147, pp. 1423- 1430 ,(1997) , 10.1093/GENETICS/147.3.1423
K. J. Keen, Robert C. Elston, Robust asymptotic sampling theory for correlations in pedigrees Statistics in Medicine. ,vol. 22, pp. 3229- 3247 ,(2003) , 10.1002/SIM.1559
Robert C. Elston, Sarah Buxbaum, Kevin B. Jacobs, Jane M. Olson, Haseman and Elston revisited. Genetic Epidemiology. ,vol. 19, pp. 1- 17 ,(2000) , 10.1002/1098-2272(200007)19:1<1::AID-GEPI1>3.0.CO;2-E
George Ebow Bonney, John M. Opitz, James F. Reynolds, On the statistical determination of major gene mechanisms in continuous human traits: Regressive models American Journal of Medical Genetics. ,vol. 18, pp. 731- 749 ,(1984) , 10.1002/AJMG.1320180420
J. K. Haseman, R. C. Elston, The investigation of linkage between a quantitative trait and a marker locus Behavior Genetics. ,vol. 2, pp. 3- 19 ,(1972) , 10.1007/BF01066731
Kyriacos Markianos, Mark J. Daly, Leonid Kruglyak, Efficient Multipoint Linkage Analysis through Reduction of Inheritance Space American Journal of Human Genetics. ,vol. 68, pp. 963- 977 ,(2001) , 10.1086/319507
R.C. Elston, J. Stewart, A General Model for the Genetic Analysis of Pedigree Data Human Heredity. ,vol. 21, pp. 523- 542 ,(1971) , 10.1159/000152448