Iron deficiency occurs frequently in children with cystic fibrosis

作者: Lieke Uijterschout , Marianne Nuijsink , Daniëlle Hendriks , Rimke Vos , Frank Brus

DOI: 10.1002/PPUL.22857

关键词:

摘要: In adult CF patients iron deficiency (ID) is common and primarily functional due to chronic inflammation. No recent data are available on the cause of ID anemia (IDA) in children with CF. Over last decades onset inflammation pulmonary disease delayed by improved nutritional status. We questioned whether occurs same extent among as patients. therefore conducted a study investigate status determine IDA associated dietary intake, lung severity Pseudomonas aeruginosa (PA) infection. Clinical charts 53 aged 0-16 were reviewed. Follow-up varied from 1 14 years 343 annual observations total. Thirty-two (60.4%) deficient at least year was present 84 (24.5%). 2011 9 (17.0%). Ten (18.9%) anemic 13 328 (4.0%). 6 (11.3%). Ferritin (Fer) positively age. Higher Fer values found older represent an increased state inflammation, rather than status, might increase relative contribution ID. This shows that relatively healthy, well-nourished The mechanism currently unknown. A prospective using both soluble transferrin receptor indicators for will provide more insight incidence causes

参考文章(22)
Joann L. Ater, John J. Herbst, Richard T. O'Brien, Stephen A. Landaw, Relative Anemia and Iron Deficiency in Cystic Fibrosis Pediatrics. ,vol. 71, pp. 810- 814 ,(1983)
M.N. Pond, A.M. Morton, S.P. Conway, Functional iron deficiency in adults with cystic fibrosis Respiratory Medicine. ,vol. 90, pp. 409- 413 ,(1996) , 10.1016/S0954-6111(96)90114-6
B Keevil, D Rowlands, I Burton, A K Webb, Assessment of iron status in cystic fibrosis patients Annals of Clinical Biochemistry. ,vol. 37, pp. 662- 665 ,(2000) , 10.1258/0004563001899708
Barry S. Skikne, Kari Punnonen, Paul H. Caldron, Michael T. Bennett, Mari Rehu, Gail H. Gasior, Janna S. Chamberlin, Linda A. Sullivan, Kurtis R. Bray, Paula C. Southwick, Improved differential diagnosis of anemia of chronic disease and iron deficiency anemia: A prospective multicenter evaluation of soluble transferrin receptor and the sTfR/log ferritin index† American Journal of Hematology. ,vol. 86, pp. 923- 927 ,(2011) , 10.1002/AJH.22108
J. B. Neilands, Siderophores: Structure and Function of Microbial Iron Transport Compounds Journal of Biological Chemistry. ,vol. 270, pp. 26723- 26726 ,(1995) , 10.1074/JBC.270.45.26723
S Cucchiara, F Santamaria, M R Andreotti, R Minella, P Ercolini, V Oggero, G de Ritis, Mechanisms of gastro-oesophageal reflux in cystic fibrosis. Archives of Disease in Childhood. ,vol. 66, pp. 617- 622 ,(1991) , 10.1136/ADC.66.5.617
R. Fischer, R. Simmerlein, R.M. Huber, H. Schiffl, S.M. Lang, Lung disease severity, chronic inflammation, iron deficiency, and erythropoietin response in adults with cystic fibrosis Pediatric Pulmonology. ,vol. 42, pp. 1193- 1197 ,(2007) , 10.1002/PPUL.20717
Z.H. Hoo, M.J. Wildman, Intravenous iron among cystic fibrosis patients Journal of Cystic Fibrosis. ,vol. 11, pp. 560- 562 ,(2012) , 10.1016/J.JCF.2012.05.002
William T. Zempsky, Effect of Pancreatic Enzyme Supplements on Iron Absorption Archives of Pediatrics & Adolescent Medicine. ,vol. 143, pp. 969- 972 ,(1989) , 10.1001/ARCHPEDI.1989.02150200131032