FGF2 modulates simultaneously the mode, the rate of division and the growth fraction in cultures of Radial Glia

摘要: ABSTRACT Radial Glial progenitors in the mammalian developing neocortex have been shown to follow a deterministic differentiation program restricted an asymmetric-only mode of division. This feature seems incompatible with their well known ability expand number when cultured vitro, driven by Fibroblast Growth Factor 2 and other mitogenic signals. The changes dynamics that allow this transition from vivo division vitro self-renewing culture not fully characterized. Here we combine experiments Glia cultures theory numerical models show has triple effect simultaneously increasing growth fraction, promoting symmetric divisions shortening length cell cycle. combined partner establish sustain pool rapidly proliferating progenitors.