Protective Effects of Magnesium Glycyrrhizinate on Methotrexate-Induced Hepatotoxicity and Intestinal Toxicity May Be by Reducing COX-2

摘要: Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese medicine Glycyrrhiza uralensis Fisch. Although the protective effects MgIG on methotrexate (MTX)-induced liver toxicity have well-documented, underlying mechanism remains elusive. MTX was initially used pediatric acute leukemia, and applied psoriasis therapy. However, its clinical applications are limited due hepatotoxicity intestinal toxicity. Herein, prophylactic administration (9 18 mg/kg/day) significantly reduced levels aspartate aminotransferase alanine in serum rats receiving intravenous injection (20 mg/kg body weight). also attenuated MTX-induced hepatic fibrosis. Moreover, it better protected against hepatocyte apoptosis decreased level malondialdehyde than glutathione (80 did. Interestingly, cyclooxygenase-2 (COX-2) expression, permeability inflammation were after administration. In addition, mg/kg) colocalization zonula occludens-1 (ZO-1) connexin 43 (Cx43) villi. conclusion, exerted beneficial damage, as potentially eligible drug for alleviating side during chemotherapy.