Pathological implications of cell aging in vitro.

摘要: The replicative capacity of cultured human fibroblasts is discussed in relation to three areas, diabetes mellitus, expression HL-A antigens, and interactions with polymerizing fibrin. cells diminished mellitus certain related disorders such as progeria Werner’s syndrome, all which feature accelerated aging. Expression antigens reduced compared normal cultures at corresponding stages passage. Normal show more subtle alteration during aging vitro probably clonal heterogeneity and/or selection within mass cultures. Early-passage interact rapidly fibrin form a mature clot then retracted by process dependent on cellular integrity active metabolism. Late-passage are less both parameters from subject progeria. These observations, total, may relate altered self-recognition autoimmune concomitants vivo. They also help explain impaired wound healing increased predisposition atherothrombosis diabetic individuals. This system should serve an excellent model investigate the molecular basis pathology.—Goldstein, S., S. Niewiarowski D. P. Singal. Pathological implications cell vitro. Federation Proc. 34: 56–63, 1975.