Expression of tetrodotoxin-resistant sodium channels in capsaicin-sensitive dorsal root ganglion neurons of adult rats
作者： J.B. Arbuckle , R.J. Docherty
DOI: 10.1016/0304-3940(94)11227-A
关键词:
摘要: We have used conventional whole-cell electrophysiological recording techniques to measure the level of expression tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in capsaicin-sensitive capsaicin-insensitive subpopulations dorsal root ganglion neurons. find that there are significantly higher levels TTX-R expressed group but no difference TTX-S. Since capsaicin is a selective stimulant polymodal nociceptors, these data raise possibility channels may be an important determinant nociceptor phenotype.
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