Interferon-γ and interleukin-1β induce nitric oxide formation from primary mouse astrocytes
作者： Sandra J. Hewett , John A. Corbett , Michael L. McDaniel , Dennis W. Choi
DOI: 10.1016/0304-3940(93)90898-U
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摘要: Abstract An inducible form of nitric oxide synthase ( i NOS) capable producing large quantities (NO) exists in some cell types. We demonstrate by immunoprecipitation and nitrite formation that interleukin-1β (IL1β) plus interferon-γ (INFγ) induce the expression primary cultures murine cortical astrocytes. This induction is time dose dependent, inhibited NOS inhibitor N G -nitro- l -arginine protein synthesis cycloheximide.
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