Association of hyperhomocysteinemia with plasma sulfate and urine sulfate excretion in patients with progressive renal disease

摘要: Abstract Background: Plasma total homocysteine (tHcy) level is increased in patients with renal disease, parallel to serum creatinine concentration. In failure, the final product of sulfated amino acid metabolism, sulfate, also accumulates as function declines. We hypothesized that elevation sulfate could cause hyperhomocysteinemia and tested relation between tHcy both urinary excretion plasma levels sulfate. Methods: Forty disease were divided into three groups: without failure (nRF; clearance [CCr] ≥ 80 mL/min/1.73 m 2 [≥1.33 mL/s/1.73 ]), mild (mRF; > CCr 25 [1.33 0.42 severe (sRF; [ ]). Daily tHcy, cysteine (tCys), measured. A healthy control (HC) group was tested. Serum methionine, taurine, vitamin B 12 , folate determined disease. Results: concentrations groups mRF sRF greater than HC group. tCys nRF Hcy Cys did not differ among four groups. urine urea nitrogen significantly less Multiple regression analyses showed (β = 0.40) 0.43) independently associated level; parameters, only daily −0.52) level. Conclusion: The elevated level, accordance function, Decreased excretion, which might intake or protein, may increase levels. Am J Kidney Dis 40:909-915. © 2002 by National Foundation, Inc.