Formoterol in the treatment of experimental cancer cachexia: effects on heart function

摘要: Background and aims Formoterol is a highly potent β2adrenoceptor-selective agonist, which muscle growth promoter in many animal species, resulting skeletal hypertrophy. Previous studies carried out our laboratory have shown that formoterol treatment tumour-bearing animals resulted an amelioration of loss through different mechanisms include apoptosis proteolysis. Methods The study presented involved rats bearing the Yoshida AH-130 ascites tumour model—which induces high degree cachexia—treated with beta-2 agonist (0.3 mg/kg BW). Results Theadministrationofformoterol tocachectic tumourbearing significant reduction weight loss. also increased lean body mass water. treatment, however, did not influence heart weight, was much decreased as result burden. Untreated showed important changes parameters related function:, left ventricle (LV) ejection fraction, fractional shortening, LV diameter volume (diastolic) stroke volume, posterior wall thickness (PWT) (both systolic diastolic). administration offormoterol affected mass. Conclusions results suggest addition to reducing wasting, does negatively alter function—in fact, some cardiac are improved—in by cancer cachexia.