Opportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal neutrons
作者： Mitra Safavi-Naeini , Andrew Chacon , Susanna Guatelli , Daniel R. Franklin , Keith Bambery
DOI: 10.1038/S41598-018-34643-W
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摘要: This paper presents Neutron Capture Enhanced Particle Therapy (NCEPT), a method for enhancing the radiation dose delivered to tumour relative surrounding healthy tissues during proton and carbon ion therapy by capturing thermal neutrons produced inside treatment volume irradiation. NCEPT utilises extant in-development boron-10 gadolinium-157-based drugs from related field of neutron capture therapy. Using Monte Carlo simulations, we demonstrate that typical or plan generates an approximately uniform within target volume, centred around beam path. The tissue concentrations agents required obtain arbitrary 10% increase in biological effective are estimated realistic plans, compared previously reported literature. We conclude proposed is theoretically feasible, can provide worthwhile improvement with readily achievable enhancement drugs.
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R. Zamenhof, J. Brenner, J. Yanch, D. Wazer, H. Madoc-Jones, S. Saris, O. Harling, Treatment Planning for Neutron Capture Therapy of Glioblastoma Multiforme Using an Epithermal Neutron Beam from the Mitr-II Research Reactor and Monte Carlo Simulation Springer, Boston, MA. pp. 173- 177 ,(1992) , 10.1007/978-1-4615-3384-9_35
Stefano Arcangeli, Thomas Zilli, Berardino De Bari, Filippo Alongi, "Hit the primary": A paradigm shift in the treatment of metastatic prostate cancer? Critical Reviews in Oncology Hematology. ,vol. 97, pp. 231- 237 ,(2016) , 10.1016/J.CRITREVONC.2015.08.023
Micah John Luderer, Pilar de la Puente, Abdel Kareem Azab, Advancements in Tumor Targeting Strategies for Boron Neutron Capture Therapy. Pharmaceutical Research. ,vol. 32, pp. 2824- 2836 ,(2015) , 10.1007/S11095-015-1718-Y
J.A. Coderre, A.D. Chanana, J. Capala, A treatment planning comparison of BPA- or BSH-based BNCT of malignant gliomas 7. international symposium on neutron capture therapy for cancer, Zurich (Switzerland), 4-7 Sep 1996. ,(1996)
Brent Drake, Thomas Grüning, Theranostics: radionuclide imaging and therapy in neuroendocrine tumours Cancer Imaging. ,vol. 15, pp. 1- 2 ,(2015) , 10.1186/1470-7330-15-S1-O16
Alfonso Gomez-Iturriaga, Jon Cacicedo, Arturo Navarro, Virginia Morillo, Patricia Willisch, Claudia Carvajal, Eduardo Hortelano, Jose Luis Lopez-Guerra, Ana Illescas, Francisco Casquero, Olga Del Hoyo, Raquel Ciervide, Ana Irasarri, Jose Ignacio Pijoan, Pedro Bilbao, Incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: multicenter prospective observational study. BMC Palliative Care. ,vol. 14, pp. 48- 48 ,(2015) , 10.1186/S12904-015-0045-8
Ian Fairlie, RBE and wR values of Auger emitters and low-range beta emitters with particular reference to tritium Journal of Radiological Protection. ,vol. 27, pp. 157- 168 ,(2007) , 10.1088/0952-4746/27/2/003
Raymond L. Moss, Critical review, with an optimistic outlook, on Boron Neutron Capture Therapy (BNCT). Applied Radiation and Isotopes. ,vol. 88, pp. 2- 11 ,(2014) , 10.1016/J.APRADISO.2013.11.109
Rolf F Barth, MG Vicente, Otto K Harling, WS Kiger 3rd, Kent J Riley, Peter J Binns, Franz M Wagner, Minoru Suzuki, Teruhito Aihara, Itsuro Kato, Shinji Kawabata, None, Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer Radiation Oncology. ,vol. 7, pp. 146- 146 ,(2012) , 10.1186/1748-717X-7-146
Hideki Ichikawa, Takeshi Uneme, Tooru Andoh, Yuya Arita, Takuya Fujimoto, Minoru Suzuki, Yoshinori Sakurai, Hiroyuki Shinto, Tomonori Fukasawa, Fumihiko Fujii, Yoshinobu Fukumori, Gadolinium-loaded chitosan nanoparticles for neutron-capture therapy: Influence of micrometric properties of the nanoparticles on tumor-killing effect. Applied Radiation and Isotopes. ,vol. 88, pp. 109- 113 ,(2014) , 10.1016/J.APRADISO.2013.12.018