Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days.

摘要: Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals 100 patients treated with 22 regimens isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone combinations. The exponential fall colony-forming was measured by linear regression coefficients the log counts during initial phase rapid, drug-determined killing and subsequent 12 days much slower sterilizing activity. first 2 varied significantly according to drug; greatest effects multiple analyses due isoniazid (p < 0.001) rifampin = 0.027). rapid kill obtained unaffected addition other drugs, so that a change activity after adding an unknown drug would not be measurable. In analysis Days 2-14, streptomycin had significant 0.007 0.006, respectively), indicating both drugs important activity, particularly early. Isoniazid pyrazinamide no effects. combined only, ethambutol effect 0.01) reverse direction suggesting it antagonized drugs.