Increasing the Dose of Vardenafil on a Daily Basis Does Not Improve Erectile Function after Unilateral Nerve‐Sparing Radical Prostatectomy

摘要: ABSTRACT Introduction Several treatment regimens for rehabilitation of erectile function (EF) after nerve‐sparing radical prostatectomy (nsRP) are currently discussed. The optimal and most cost‐effective therapy is still not found yet. Aim To evaluate the effect vardenafil, a PDE5 inhibitor, dose escalation on recovery EF unilateral nsRP. Methods Thirty‐six sexually active patients received All completed an International Index Erectile Function—5 items (IIEF‐5) questionnaire concerning preoperatively. Group 1 (N = 12 patients) vardenafil 5 mg/day vs. group 2 (N = 12) who 10 mg/day at night beginning day catheter removal. A control 12 underwent follow‐up without inhibitors. Main Outcome Measure IIEF‐5 was primary end point. questionnaires were baseline, 3, 6, months Results In (5 mg/day vardenafil) score decreased from preoperative 22.4 mean to 4.2 3 months, 8.9 6 13.4 nsRP 22.8, 4.1 7.9 12.8 in (10 mg/day vardenafil). 21.9 3.8 6.1 months. Statistical evaluation showed significant difference time between groups ( P Conclusions Daily low‐dose lead improvement EF. this study doubling dosage did improve further. Bannowsky A, van Ahlen H, Loch T. Increasing daily basis does prostatectomy. J Sex Med 2012;9:1448–1453.