Current biomarkers for diagnosing of prostate cancer
作者： Carsten Stephan , Klaus Jung , Bernhard Ralla
DOI: 10.2217/FON.15.203
关键词:
摘要: Prostate cancer (PCa) is mostly detected by prostate-specific antigen (PSA) as one of the most widely used tumor markers. But PSA limited with its low specificity. The prostate health index (phi) can improve specificity over percent free and total correlates aggressive cancer. urinary PCA3 also shows utility to detect PCa but correlation aggressiveness sensitivity at high values are limitations. While detection alterations androgen-regulated TMPRSS2 ETS transcription factor genes in tissue ˜50% all patients was research milestone, assay should only be combination PCA3. Both US FDA-approved markers phi perform equally.
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