Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy

摘要: Rodent 13C magnetic resonance spectroscopy studies show that glutamatergic signaling requires high oxidative energy in the awake resting state and allowed calibration of functional imaging (fMRI) signal terms relative to energy. Here, we derived used for human. We analyzed human data electroencephalography (EEG), positron emission tomography (PET) maps oxygen (CMRO2) glucose (CMRglc) utilization, calibrated fMRI from a variety experimental conditions. CMRglc EEG visual cortex were tightly coupled over several conditions, showing demand was four times greater than nonsignaling events state. Variations CMRO2 gray-matter regions networks within ±10% means, suggesting most areas required similar ubiquitously activity. Human results suggest changes cognitive contribute at rest. The PET sleep, vegetative state, anesthesia metabolic reductions rest, uniformly >20% across, indicating no region is selectively reduced when consciousness lost. Future clinical investigations will benefit using quantitative measures.