作者: Wu-Chien Chien , Yu-Chen Kao , Nian-Sheng Tzeng , Hsin-An Chang , Fang-Jung Wan
DOI: 10.2147/NDT.S268360
关键词:
摘要: Background Multiple sclerosis (MS) is a demyelinating disease that can damage neurons in the brain and spinal cord associated with several psychiatric disorders. However, few studies have evaluated risk of disorders patients MS by using nationwide database. This study investigated association between Methods Using data from Taiwan National Health Insurance Research Database 2000 to 2015, we identified 1066 MS. After adjustment for confounding factors, Fine Gray's competing model was used compare during 15 years follow-up. Results Of MS, 531 (4622.86 per 105 person years) developed disorders; contrast, 891 3198 controls (2485.31 revealed an adjusted hazard ratio (HR) 5.044 (95% confidence interval = 4.448-5.870, p Conclusion Patients were determined higher developing wide range