Early Treatment With Enalapril and Later Renal Injury in Programmed Obese Adult Rats.

摘要: Obesity-related kidney disease should be prevented or retarded. We aimed to investigate whether early treatment with enalapril ameliorates later renal injury induced by postnatal overnutrition. Three ten male pups per mother were assigned either the Obese Lean group during first 21 days of life. These treated (Obese enalapril, OE; LE) vehicle control, OC; LC) for 15-28 days. Body weight, blood pressure (BP), and alterations determined at 3 months. Enalapril decreased body weight only in months (P < 0.05). Systemic BP levels higher LE, OC, OE groups than LC Fewer glomeruli section area found OC The LE had index scores glomerulosclerosis tubulointerstitial fibrosis controls showed increased intrarenal angiotensin II receptor type (AT)2 matrix metalloproteinase (MMP)-9 renin tissue inhibitor MMP (TIMP)-1 expression rats AT2 AT1 TIMP-1 In conclusion, can induce detrimental effects life may not renoprotective programmed obese adult rats. J. Cell. Physiol. 232: 447-455, 2017. © 2016 Wiley Periodicals, Inc.