Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer.
作者： Christoph Loddenkemper , Corinna Hoffmann , Jonas Stanke , Dirk Nagorsen , Udo Baron
DOI: 10.1111/J.1349-7006.2009.01153.X
关键词:
摘要: Regulatory (FOXP3+) T cells (Tregs) comprise a subpopulation of CD4+ that suppress autoreactive immune cells, thereby protecting organs and tissues from autoimmunity. Tregs have also been detected in human malignancies their depletion or inactivation substantially improves cellular antitumor immunity preclinical studies. Novel therapeutic strategies for cervical cancer precancerous intraepithelial neoplasia (CIN) focus on immune-modulatory vaccination approaches. In this context, the frequency CIN could influence strategies. We determined infiltrating CD8+ as well FOXP3+ high-grade lesions (CIN III) carcinoma compared to colon carcinoma, skin melanoma, bronchial carcinoma. show papilloma virus-derived significantly higher number lymphocytes three other common tumor entities. addition we explored effect agonistic anti-glucocorticoid-induced necrosis factor receptor family-related protein antibodies that, by single systemic application, inactivate induce strong intratumoral invasion complete eradication 70% treated animals. The large suggests pivotal role counteracting host response. therefore regard prime targets new immune-based non-invasive therapies.
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