Gene Expression Profile and Prognostic Value of m6A RNA Methylation Regulators in Hepatocellular Carcinoma.
作者： Xian Chang , Yang-Fan Lv , Qiao-Nan Guo , Jing He , Ya Cao
DOI: 10.2147/JHC.S296438
关键词:
摘要: Background N6-methyladenosine (m6A) RNA methylation is the most prevalent modification of mammalian RNA, and it associated with tumorigenesis cancer progression. Its regulation mediated via m6A-related regulators, including "erasers," "readers," "writers". The present study evaluated expression profile, risk signature prognostic value 13 m6A regulators in hepatocellular carcinoma (HCC) using different datasets, Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) clinical samples. Methods We used 374 HCC samples derived from TCGA database, 569 2 GEO tumour nontumour tissues 60 patients who underwent surgery Xinqiao Hospital Chongqing to assess gene profiles values HCC. Results Eight core were overexpressed all databases, TCGA, GSE, Two clusters (Cluster 1 Cluster 2) identified consensus clustering. was poorer prognosis, higher grade, AFP levels, worse outcome compared 1, which indicates that these are highly correlated malignancy. performed survival analyses Log rank tests a Cox regression model. enrichment analysis detect related KEGG GO pathways. five selected regulators. Conclusion Our work suggested might be key participants progression potential biomarkers value.
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