Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.

摘要: Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies integrated multimodal imaging simultaneously investigate relationships among structure, function, cognition. We aimed clarify how specifically DLPFC contribute memory healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging were divided into higher lower groups based on a median split of in-scanner n-back task performance. Three priori spherical regions interest (ROIs) used quantify blood-oxygen-level-dependent (BOLD) signal FreeSurfer-derived surface area, cortical thickness, white matter volume. Binary logistic regressions adjusting for age, sex, education, scanner type revealed that greater left right BOLD predicted the probability performing group membership (P values .05). Importantly, this suggests area may independently performance