Die fibrovaskuläre Umwandlung der CNV bei nAMD unter lang andauernder Anti-VEGF-Therapie
作者： Henrik Faatz , Matthias Gutfleisch , Daniel Pauleikhoff , Albrecht Lommatzsch , Georg Spital
DOI: 10.1007/S00347-020-01261-9
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摘要: Bei der neovaskularen altersabhangiger Makuladegeneration (nAMD) kann es unter lang andauernder Anti-VEGF-Therapie zu einer fibrovaskularen Umwandlung choroidalen Neovaskularisation (CNV) kommen. Es fehlen Definitionen, wie eine differenzierte Quantifizierung einhergehenden morphologischen Veranderungen erfolgen kann. Die vorliegende Pilotstudie dient dem Ziel, die hierzu am besten geeigneten Bildgebungsmodalitaten definieren. 56 Augen mit fibrosierter CNV nach min. 2 jahriger und 12 intravitrealen Anti-VEGF-Injektionen wurden folgenden hinsichtlich Abgrenzbarkeit von vaskularem fibrosem Anteil sowie assoziierter Atrophie retinalem Pigmentepithel (RPE) Unterbrechung ellipsoiden Zone (EZ) untersucht: Multicoloraufnahme (MC), Fundusautofluoreszenz (FAF), Fluoreszeinangiographie (FA) Indocyaningrunangiographie (ICGA), Spectral-domain-optische Koharenztomographie (SD-OCT) OCT-Angiographie (OCTA). Der vaskulare fibrosierten konnte mittels OCTA, fibrose SD-OCT abgegrenzt werden. RPE-Atrophie war bestmoglich FAF darstellbar, jedoch Abgrenzung auch mithilfe MC ICGA moglich. EZ-Unterbrechung im SD-OCT-b-Scan ist zur Darstellung CNV, geeignet. Mittels quantifiziert werden; b Scan, nicht transverse-structure-Scan abgrenzbar. Mithilfe OCTA Detektion des vaskularen Anteils
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Christine A Curcio, Chandrakumar Balaratnasingam, Jeffrey D Messinger, Lawrence A Yannuzzi, K Bailey Freund, None, Correlation of Type 1 Neovascularization Associated With Acquired Vitelliform Lesion in the Setting of Age-Related Macular Degeneration. American Journal of Ophthalmology. ,vol. 160, pp. 1024- 1033 ,(2015) , 10.1016/J.AJO.2015.08.001
Richard F. Spaide, Optical Coherence Tomography Angiography Signs of Vascular Abnormalization With Antiangiogenic Therapy for Choroidal Neovascularization American Journal of Ophthalmology. ,vol. 160, pp. 6- 16 ,(2015) , 10.1016/J.AJO.2015.04.012
Ebenezer Daniel, Cynthia A Toth, Juan E Grunwald, Glenn J Jaffe, Daniel F Martin, Stuart L Fine, Jiayan Huang, Gui-shuang Ying, Stephanie A Hagstrom, Katrina Winter, Maureen G Maguire, Comparison of Age-related Macular Degeneration Treatments Trials Research Group, Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials Ophthalmology. ,vol. 121, pp. 656- 666 ,(2014) , 10.1016/J.OPHTHA.2013.10.019
Young Gun Park, Hyun Wook Rhu, Seungbum Kang, Young Jung Roh, New Approach of Anti-VEGF Agents for Age-Related Macular Degeneration. Journal of Ophthalmology. ,vol. 2012, pp. 637316- 637316 ,(2012) , 10.1155/2012/637316
Ursula Schmidt-Erfurth, Victor Chong, Anat Loewenstein, Michael Larsen, Eric Souied, Reinier Schlingemann, Bora Eldem, Jordi Monés, Gisbert Richard, Francesco Bandello, Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA) British Journal of Ophthalmology. ,vol. 98, pp. 1144- 1167 ,(2014) , 10.1136/BJOPHTHALMOL-2014-305702
Alex S Willoughby, Gui-shuang Ying, Cynthia A Toth, Maureen G Maguire, Russell E Burns, Juan E Grunwald, Ebenezer Daniel, Glenn J Jaffe, David F Williams, Sara Beardsley, Steven Bennett, Herbert Cantrill, Carmen Chan-Tram, Holly Cheshier, Kathyrn Damato, John Davies, Sundeep Dev, Julianne Enloe, Gennaro Follano, Peggy Gilbert, Jill Johnson, Tori Jones, Lisa Mayleben, Robert Mittra, Martha Moos, Ryan Neist, Neal Oestreich, Polly Quiram, Robert Ramsay, Edwin Ryan, Stephanie Schindeldecker, John Snater, Trenise Steele, Dwight Selders, Jessica Tonsfeldt, Shelly Valardi, Gary Edd Fish, Hank A Aguado, Sally Arceneaux, Jean Arnwine, Kim Bell, Tina Bell, Bob Boleman, Patricia Bradley, David Callanan, Lori Coors, Jodi Creighton, Timothy Crew, Kimberly Cummings, Christopher Dock, Karen Duignan, Dwain Fuller, Keith Gray, Betsy Hendrix, Nicholas Hesse, Diana Jaramillo, Bradley Jost, Sandy Lash, Laura Lonsdale, Michael Mackens, Karin Mutz, Michael Potts, Brenda Sanchez, William Snyder, Wayne Solley, Carrie Tarter, Robert Wang, Patrick Williams, Stephen L Perkins, Nicholas Anderson, Ann Arnold, Paul Blais, Joseph Googe, Tina T Higdon, Cecile Hunt, Mary Johnson, James Miller, Misty Moore, Charity K Morris, Christopher Morris, Sarah Oelrich, Kristina Oliver, Vicky Seitz, Jerry Whetstone, Bernard H Doft, Jay Bedel, Robert Bergren, Ann Borthwick, Paul Conrad, Amanda Fec, Christina Fulwylie, Willia Ingram, Shawnique Latham, Gina Lester, Judy Liu, Louis Lobes, Nicole M Lucko, Holly Mechling, Lori Merlotti, Keith McBroom, Karl Olsen, Danielle Puskas, Pamela Rath, Maria Schmucker, Lynn Schueckler, Christina Schultz, Heather Shultz, David Steinberg, Avni Vyas, Kim Whale, Kimberly Yeckel, David H Orth, Linda S Arredondo, Susan Brown, Barbara J Ciscato, Joseph M Civantos, Celeste Figliulo, Sohail Hasan, Belinda Kosinski, Dan Muir, Kiersten Nelson, Kirk Packo, John S Pollack, Kourous Rezaei, Gina Shelton, Shannya Townsend-Patrick, Marian Walsh, H Richard McDonald, Nina Ansari, Amanda Bye, Arthur D Fu, Sean Grout, Chad Indermill, Robert N Johnson, J Michael Jumper, Silvia Linares, Brandon J Lujan, Ames Munden, Meredith Persons, Rosa Rodriguez, Jennifer M Rose, Brandi Teske, Yesmin Urias, Stephen Young, Richard F Dreyer, Howard Daniel, Michele Connaughton, Irvin Handelman, Stephen Hobbs, Christine Hoerner, None, Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials Ophthalmology. ,vol. 122, pp. 1846- 1853 ,(2015) , 10.1016/J.OPHTHA.2015.05.042
Wan Ling Wong, Xinyi Su, Xiang Li, Chui Ming G Cheung, Ronald Klein, Ching-Yu Cheng, Tien Yin Wong, Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health. ,vol. 2, ,(2014) , 10.1016/S2214-109X(13)70145-1
Madeline Yung, Michael A. Klufas, David Sarraf, Clinical applications of fundus autofluorescence in retinal disease International Journal of Retina and Vitreous. ,vol. 2, pp. 12- ,(2016) , 10.1186/S40942-016-0035-X
Philipp Roberts, Mitsuro Sugita, Gábor Deák, Bernhard Baumann, Stefan Zotter, Michael Pircher, Stefan Sacu, Christoph K. Hitzenberger, Ursula Schmidt-Erfurth, Automated Identification and Quantification of Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration Using Polarization-Sensitive OCT. Investigative Ophthalmology & Visual Science. ,vol. 57, pp. 1699- 1705 ,(2016) , 10.1167/IOVS.15-18694
Marie-Louise Farecki, Matthias Gutfleisch, Henrik Faatz, Kai Rothaus, Britta Heimes, Georg Spital, Albrecht Lommatzsch, Daniel Pauleikhoff, Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography Graefes Archive for Clinical and Experimental Ophthalmology. ,vol. 255, pp. 913- 921 ,(2017) , 10.1007/S00417-017-3588-Y