Combining sodium-dependent glucose co-transporter 2 inhibition with conventional diuretics: Dr Jekyll and Mr Hyde?

Norm Rosenthal, Gary Meininger, Kirk Ways, David Polidori, Mehul Desai, Rong Qiu, Maria Alba, Frank Vercruysse, Dainius Balis, Wayne Shaw, Robert Edwards, Scott Bull, Nicholas Di Prospero, Sue Sha, Paul Rothenberg, William Canovatchel, Keith Demarest, Canagliflozin: a sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes mellitus. Annals of the New York Academy of Sciences. ,vol. 1358, pp. 28- 43 ,(2015) , 10.1111/NYAS.12852

Julie O'Neill, Angelica Fasching, Liselotte Pihl, Daniela Patinha, Stephanie Franzén, Fredrik Palm, Acute SGLT inhibition normalizes O2 tension in the renal cortex but causes hypoxia in the renal medulla in anaesthetized control and diabetic rats American Journal of Physiology-renal Physiology. ,vol. 309, ,(2015) , 10.1152/AJPRENAL.00689.2014

Helge Wiig, Agnes Schröder, Wolfgang Neuhofer, Jonathan Jantsch, Christoph Kopp, Tine V. Karlsen, Michael Boschmann, Jennifer Goss, Maija Bry, Natalia Rakova, Anke Dahlmann, Sven Brenner, Olav Tenstad, Harri Nurmi, Eero Mervaala, Hubertus Wagner, Franz-Xaver Beck, Dominik N. Müller, Dontscho Kerjaschki, Friedrich C. Luft, David G. Harrison, Kari Alitalo, Jens Titze, Immune cells control skin lymphatic electrolyte homeostasis and blood pressure Journal of Clinical Investigation. ,vol. 123, pp. 2803- 2815 ,(2013) , 10.1172/JCI60113

Agnes Machnik, Wolfgang Neuhofer, Jonathan Jantsch, Anke Dahlmann, Tuomas Tammela, Katharina Machura, Joon-Keun Park, Franz-Xaver Beck, Dominik N Müller, Wolfgang Derer, Jennifer Goss, Agata Ziomber, Peter Dietsch, Hubertus Wagner, Nico Van Rooijen, Armin Kurtz, Karl F Hilgers, Kari Alitalo, Kai-Uwe Eckardt, Friedrich C Luft, Dontscho Kerjaschki, Jens Titze, None, Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism Nature Medicine. ,vol. 15, pp. 545- 552 ,(2009) , 10.1038/NM.1960

S. Sha, D. Polidori, T. Heise, J. Natarajan, K. Farrell, S.-S. Wang, D. Sica, P. Rothenberg, L. Plum-Mörschel, Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes, Obesity and Metabolism. ,vol. 16, pp. 1087- 1095 ,(2014) , 10.1111/DOM.12322

Damayanthi Devineni, Nicole Vaccaro, David Polidori, Sarah Rusch, Ewa Wajs, Effects of hydrochlorothiazide on the pharmacokinetics, pharmacodynamics, and tolerability of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants. Clinical Therapeutics. ,vol. 36, pp. 698- 710 ,(2014) , 10.1016/J.CLINTHERA.2014.02.022

M.C. Thomas, K. Jandeleit-Dahm, F. Bonnet, Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes Diabetes & Metabolism. ,vol. 40, ,(2014) , 10.1016/S1262-3636(14)72691-6

M. A. Abdul-Ghani, R. A. DeFronzo, L. Norton, Novel Hypothesis to Explain Why SGLT2 Inhibitors Inhibit Only 30–50% of Filtered Glucose Load in Humans Diabetes. ,vol. 62, pp. 3324- 3328 ,(2013) , 10.2337/DB13-0604

R. Santer, Molecular Analysis of the SGLT2 Gene in Patients with Renal Glucosuria Journal of the American Society of Nephrology. ,vol. 14, pp. 2873- 2882 ,(2003) , 10.1097/01.ASN.0000092790.89332.D2

Volker Vallon, The Mechanisms and Therapeutic Potential of SGLT2 Inhibitors in Diabetes Mellitus Annual Review of Medicine. ,vol. 66, pp. 255- 270 ,(2015) , 10.1146/ANNUREV-MED-051013-110046