Aspergillus spp. invasive external otitis: favourable outcome with a medical approach.

作者: E. Marchionni , P. Parize , A. Lefevre , P. Vironneau , M.E. Bougnoux

DOI: 10.1016/J.CMI.2015.12.027

关键词:

摘要: Aspergillus spp. invasive external otitis (IEO) is a rare infection. We performed seven-year, single-centre retrospective study from 2007 to 2014 including all patients with proven IEO. Twelve were identified. All had poorly controlled diabetes mellitus and one underwent solid organ transplant. The most frequently isolated species was flavus (n = 10) voriconazole the first-line therapy in cases, median length of treatment 338.5 days (158-804 days). None extensive surgery. clinical outcome excellent. However, otological sequelae reported, hearing impairment (n = 7) facial palsy (n = 3).

参考文章(20)
Dominik Stodulski, Bożena Kowalska, Czesław Stankiewicz, Otogenic skull base osteomyelitis caused by invasive fungal infection. Case report and literature review. European Archives of Oto-rhino-laryngology. ,vol. 263, pp. 1070- 1076 ,(2006) , 10.1007/S00405-006-0118-7
Olivier Lortholary, J-P Gangneux, Karine Sitbon, Bernadette Lebeau, Frédérique De Monbrison, Yann Le Strat, Bruno Coignard, Françoise Dromer, Stéphane Bretagne, French Mycosis Study Group, Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005–2007) Clinical Microbiology and Infection. ,vol. 17, pp. 1882- 1889 ,(2011) , 10.1111/J.1469-0691.2011.03548.X
Corine E Delsing, Katharina L Becker, Anna Simon, Bart Jan Kullberg, Chantal P Bleeker-Rovers, Frank L van de Veerdonk, Mihai G Netea, Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis. BMC Infectious Diseases. ,vol. 15, pp. 140- 140 ,(2015) , 10.1186/S12879-015-0891-2
Gal Finer, David Greenberg, Eugene Leibovitz, Alberto Leiberman, Ilan Shelef, Joseph Kapelushnik, Conservative treatment of malignant (invasive) external otitis caused by Aspergillus flavus with oral itraconazole solution in a neutropenic patient Scandinavian Journal of Infectious Diseases. ,vol. 34, pp. 227- 229 ,(2002) , 10.1080/00365540110077137
Arunaloke Chakrabarti, Ashim Das, Jharna Mandal, M. R. Shivaprakash, Varghese K. George, Bansidhar Tarai, Pooja Rao, Naresh Panda, Subhash C. Verma, Vinay Sakhuja, The rising trend of invasive zygomycosis in patients with uncontrolled diabetes mellitus Medical Mycology. ,vol. 44, pp. 335- 342 ,(2006) , 10.1080/13693780500464930
Maria N. Gamaletsou, Blandine Rammaert, Marimelle A. Bueno, Brad Moriyama, Nikolaos V. Sipsas, Dimitrios P. Kontoyiannis, Emmanuel Roilides, Valerie Zeller, Roberta Prinapori, Saad J. Taj-Aldeen, Barry Brause, Olivier Lortholary, Thomas J. Walsh, Aspergillus osteomyelitis: epidemiology, clinical manifestations, management, and outcome. Journal of Infection. ,vol. 68, pp. 478- 493 ,(2014) , 10.1016/J.JINF.2013.12.008
Jenny Walton, Chris Coulson, Fungal Malignant Otitis Externa with Facial Nerve Palsy: Tissue Biopsy Aids Diagnosis Case reports in otolaryngology. ,vol. 2014, pp. 192318- 192318 ,(2014) , 10.1155/2014/192318
Alexandra Schuetz, Claire Deleage, Irini Sereti, Rungsun Rerknimitr, Nittaya Phanuphak, Yuwadee Phuang-Ngern, Jacob D Estes, Netanya G Sandler, Suchada Sukhumvittaya, Mary Marovich, Surat Jongrakthaitae, Siriwat Akapirat, James LK Fletscher, Eugene Kroon, Robin Dewar, Rapee Trichavaroj, Nitiya Chomchey, Daniel C Douek, Robert J O′ Connell, Viseth Ngauy, Merlin L Robb, Praphan Phanuphak, Nelson L Michael, Jean-Louis Excler, Jerome H Kim, Mark S de Souza, Jintanat Ananworanich, RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups, None, Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation PLoS Pathogens. ,vol. 10, pp. e1004543- ,(2014) , 10.1371/JOURNAL.PPAT.1004543
R. Araujo, A. G. Rodrigues, Variability of Germinative Potential among Pathogenic Species of Aspergillus Journal of Clinical Microbiology. ,vol. 42, pp. 4335- 4337 ,(2004) , 10.1128/JCM.42.9.4335-4337.2004
Suzanne E Geerlings, Andy I.M Hoepelman, Immune dysfunction in patients with diabetes mellitus (DM) Fems Immunology and Medical Microbiology. ,vol. 26, pp. 259- 265 ,(1999) , 10.1111/J.1574-695X.1999.TB01397.X