Pituitary and Gonadal Desensitization after Continuous Luteinizing Hormone-Releasing Hormone Infusion in Normal Females*

摘要: Three normal females were studied during the early follicular phase of menstrual cycle employing a continuous infusion LHRH (1.4 µg/min) for 72 h. Blood samples taken every 4 LH concentrations climbed from 9.3 mlU/ml basally to peak values 129 at 12 h, then fell plateau between 23–31 36–72 FSH levels rose 5.4 36 h and returned baseline. 17β-Estradiol increased 48 184 pg/ml 32 but subsequently toward basal concentrations. 17-Hydroxyprogesterone 0.5 1.23 ng/ml remained elevated remainder period. Serum progesterone constant. with premature ovarian failure studied, pattern gonadotropin release was similar that subjects. Studies demonstrate in causes pituitary gonadal desensitization. The desensitization is independent ac...