Neurotransmitters as Main Players in the Neural Differentiation and Fate Determination Game

摘要: The wide phenotypic variety of individual cells in the CNS and enormous complexity network formed between these results from specific development programs which direct differentiation stem progenitor into numerous types neurons as well astrocytes oligodendrocytes. It is believed that addition to activation intrinsic genetic programs, extrinsic factors are needed for progress neural phenotype determination. Recent studies have revealed classical growth factors, neurotransmitters morphogenic functions. Calcium signaling triggered by ion channels or metabotropic receptors codified a frequency transients (peaks waves) leads initiation calcium-dependent gene expression program essential next stage. We discuss evidence pointing participation GABA, glutamate, cholinergic purinergic neuronal various cell models.