A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Juan R. Cubillos-Ruiz, Pedro C. Silberman, Melanie R. Rutkowski, Sahil Chopra, Alfredo Perales-Puchalt, Minkyung Song, Sheng Zhang, Sarah E. Bettigole, Divya Gupta, Kevin Holcomb, Lora H. Ellenson, Thomas Caputo, Ann-Hwee Lee, Jose R. Conejo-Garcia, Laurie H. Glimcher, ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis Cell. ,vol. 161, pp. 1527- 1538 ,(2015) , 10.1016/J.CELL.2015.05.025

Harold D. Kim, Tal Shay, Erin K. O’Shea, Aviv Regev, Transcriptional regulatory circuits: predicting numbers from alphabets. Science. ,vol. 325, pp. 429- 432 ,(2009) , 10.1126/SCIENCE.1171347

G. Hagens, F. Songeon, N. Boehringer, L.P. Nicod, P. Isler, Differential regulation of tumor necrosing factor-alpha (TNF-alpha) and interleukin-10 (IL-10) secretion by protein kinase and phosphatase inhibitors in human alveolar macrophages. European Cytokine Network. ,vol. 10, pp. 211- 217 ,(1999)

Carlos Sebastián, Maria Serra, Andrée Yeramian, Neus Serrat, Jorge Lloberas, Antonio Celada, Deacetylase Activity Is Required for STAT5-Dependent GM-CSF Functional Activity in Macrophages and Differentiation to Dendritic Cells Journal of Immunology. ,vol. 180, pp. 5898- 5906 ,(2008) , 10.4049/JIMMUNOL.180.9.5898

Eva Faurobert, Corinne Albiges-Rizo, Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction. FEBS Journal. ,vol. 277, pp. 1084- 1096 ,(2010) , 10.1111/J.1742-4658.2009.07537.X

Judith A. Jaehning, The Paf1 complex: Platform or player in RNA polymerase II transcription? Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. ,vol. 1799, pp. 379- 388 ,(2010) , 10.1016/J.BBAGRM.2010.01.001

John G Doench, Ella Hartenian, Daniel B Graham, Zuzana Tothova, Mudra Hegde, Ian Smith, Meagan Sullender, Benjamin L Ebert, Ramnik J Xavier, David E Root, Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation Nature Biotechnology. ,vol. 32, pp. 1262- 1267 ,(2014) , 10.1038/NBT.3026

Roxane Tussiwand, Wan-Ling Lee, Theresa L. Murphy, Mona Mashayekhi, Wumesh KC, Jörn C. Albring, Ansuman T. Satpathy, Jeffrey A. Rotondo, Brian T. Edelson, Nicole M. Kretzer, Xiaodi Wu, Leslie A. Weiss, Elke Glasmacher, Peng Li, Wei Liao, Michael Behnke, Samuel S. K. Lam, Cora T. Aurthur, Warren J. Leonard, Harinder Singh, Christina L. Stallings, L. David Sibley, Robert D. Schreiber, Kenneth M. Murphy, Compensatory dendritic cell development mediated by BATF–IRF interactions Nature. ,vol. 490, pp. 502- 507 ,(2012) , 10.1038/NATURE11531

James Kelley, Bernard de Bono, John Trowsdale, IRIS: A database surveying known human immune system genes Genomics. ,vol. 85, pp. 503- 511 ,(2005) , 10.1016/J.YGENO.2005.01.009

Randall J. Platt, Sidi Chen, Yang Zhou, Michael J. Yim, Lukasz Swiech, Hannah R. Kempton, James E. Dahlman, Oren Parnas, Thomas M. Eisenhaure, Marko Jovanovic, Daniel B. Graham, Siddharth Jhunjhunwala, Matthias Heidenreich, Ramnik J. Xavier, Robert Langer, Daniel G. Anderson, Nir Hacohen, Aviv Regev, Guoping Feng, Phillip A. Sharp, Feng Zhang, CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling Cell. ,vol. 159, pp. 440- 455 ,(2014) , 10.1016/J.CELL.2014.09.014