GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs

摘要: Receptor activity-modifying proteins (RAMPs) are widely expressed in human tissues and, some cases, have been shown to affect surface expression or ligand specificity of G-protein-coupled receptors (GPCRs). However, whether RAMP-GPCR interactions widespread, and the nature their functional consequences, remains largely unknown. In humans, there three RAMPs over 800 GPCRs, making direct experimental approaches challenging. We analyzed relevant genomic data from all currently available sequenced organisms. discovered that GPCRs tend orthologs same species correlated phylogenetic trees extent, higher than other interacting protein pairs play key roles cellular signaling. addition, resulting interaction map suggests RAMP1 RAMP3 interact with set which implies redundancy. next transcriptomes found correlation for RAMPs. Our results suggest global coevolution RAMPS support hypothesis globally signaling pathways.