The CANLPH Score, an Integrative Model of Systemic Inflammation and Nutrition Status (SINS), Predicts Clinical Outcomes After Surgery in Renal Cell Carcinoma: Data From a Multicenter Cohort in Japan

摘要: A myriad of studies have demonstrated the clinical association systemic inflammatory and nutrition status (SINS) including C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte (NLR), platelet/hemoglobin (PHR). This study aimed to investigate predictive value score integrating these variables (CANLPH) in patients with renal cell carcinoma (RCC). Using cohort data from a multi-institutional study, 757 1109 were retrospectively analyzed. The optimal cutoff for outcome prediction continuous CAR, NLR, PHR was determined CANLPH then calculated as sum 0 or 1 by each ratio. median follow-up time 76 months who survived (n = 585) 31 months those died (n = 172). Youden Index offered an 1.5 CAR 2.8 higher assigned 1. defined 2.1 males 2.3 females. (47.2%), (31.3%), 2 (13.1%), 3 (8.5%). In multivariate analysis, served independent predictor cancer-specific mortality both localized metastatic RCC. well-correlated RCC patients. Because this can be concisely measured at point diagnosis, physicians may encouraged incorporate model into treatment