A Protective Vaccine against Johne's Disease in Cattle.

摘要: Johne’s disease (JD) caused by Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) is a chronic infection characterized the development of granulomatous enteritis in wild and domesticated ruminants. It one most significant livestock diseases not only USA but also globally, accounting for USD 200–500 million losses annually alone with potential link to cases Crohn’s humans. Developing safe protective vaccines paramount importance JD control dairy cows. The current study evaluated safety, immunity efficacy novel live attenuated vaccine (LAV) candidate without an adjuvant comparison inactivated vaccine. Results indicated that LAV, irrespective presence, induced robust T cell immune responses proinflammatory cytokine production such as IFN-γ, IFN-α, TNF-α IL-17 well strong response intradermal skin test against M. antigens. Furthermore, LAV was minimal tissue pathology. Finally, calves vaccinated adjuvanted did shed post-challenge, much-desired characteristic effective JD. Together, this data suggests testing field trials curb herds.