Cytotoxic pyrrolo- and furanoterpenoids from the sponge sarcotragus species.

摘要: Reexamination of the configuration sarcotins A-C, first isolated from marine sponge Sarcotragus sp., revealed that proposed stereochemistry tetronic acid moiety needs to be revised as shown in 1-3. Additional new pyrrolosesterterpenes (5-11), furanosesterpene derivatives (4, 12-14, 19), and furanoterpenoids, including two trinorsesterterpenes (15, 16) diterpenes (17, 18), were same by bioactivity-guided fractionation. The planar structures established on basis NMR MS analysis. was defined combined use NMR, CD spectroscopy, chemical degradation. compounds evaluated for cytotoxicity against five human tumor cell lines found exhibit moderate significant activity.