Clinical management of HIV-1 resistance.

摘要: Abstract Antiretroviral drug resistance is a fundamental survival strategy for the virus that stems from its vast capacity to generate diversity. With recent availability of new ARV drugs and classes, it now possible prescribe fully active ART most HIV-infected subjects achieve viral suppression even in those with multidrug-resistant HIV. It uncertain, however, if this scenario will endure. Given must be given life, compounds other than second-generation integrase inhibitors may not reach clinic soon, all efforts done avoid development agents. Here, we discuss relevant aspects clinical management antiretroviral resistance, leaving detailed explanations mechanisms mutation patterns articles issue. This article forms part special issue Antiviral Research marking 25th anniversary discovery development, vol. 85, 1, 2010.