Microscopic gastrointestinal stromal tumours: a clinical and molecular study of 13 cases.

摘要: Aims Recent literature suggests that clinically silent, microscopic gastrointestinal stromal tumours (micro-GISTs) are common incidental findings. The aim of this study was to examine the histological, immunohistochemical and molecular characteristics these tumours, which we have defined as measuring ≤20 mm, in order determine whether rate spectrum mutations similar those symptomatic (GISTs). Methods results Thirteen micro-GISTs identified findings patients undergoing management concomitant disease were tested for KIT/PDGFRA mutations. Ten (77%) located stomach, two (15%) duodenum, one (8%) rectum. mean tumour size 9.3 mm (range 2–19 mm). All well-circumscribed lesions showing a predominantly spindle-cell morphology very low mitotic rate. Twelve 13 (92%) carried either KIT (83%) or PDGFRA (17%), higher than other published series. A high mutation (80%) also seen ≤5 mm. Conclusions Our results suggest is early event GIST development, does not reliably predict presence mutation, more subsequent required clinical manifestation.